Abstract
Dibenzo[b,h][1,6]naphthyridines were synthesized in one pot by reacting 2-acetylaminobenzaldehyde with methyl ketones under basic conditions via four sequential condensation reactions. This method was also applied to the synthesis of 1,2-dihydroquinolines. 6-Methyl-1,6-dibenzonaphthyridinium triflates showed strong fluorescence, and the fluorescence intensities were changed upon intercalation into double-stranded DNA.
MeSH terms
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Benzaldehydes / chemistry
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DNA / chemistry*
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Fluorescence
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Fluorescent Dyes / chemical synthesis*
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Fluorescent Dyes / chemistry
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Intercalating Agents / chemical synthesis*
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Intercalating Agents / chemistry
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Ketones / chemistry
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Naphthyridines / chemical synthesis*
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Naphthyridines / chemistry
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Quinolines / chemical synthesis
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Quinolines / chemistry
Substances
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1,4-dihydroquinoline
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Benzaldehydes
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Fluorescent Dyes
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Intercalating Agents
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Ketones
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Naphthyridines
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Quinolines
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DNA