A new α-pyrone derivative, compound 2, and a known one, cladobotrin V, were isolated from the culture broth of the mangrove endophyte Fusarium sp. IM-37. Their structures were determined spectroscopically and compared with previously reported spectral data. Compound 2 restored the growth inhibition caused by hyperactivated Ca(2+)-signaling in mutant yeast.
Keywords: Ca2+-signaling; Fusarium sp; cladobotrin V; endophyte; mangrove.