Serological misdiagnosis of acute liver failure associated with echovirus 25 due to immunological similarities to hepatitis A virus and prozone effect

Susan K Wollersheim; Romney M Humphries; James D Cherry; Paul Krogstad

doi:10.1128/JCM.02724-14

Serological misdiagnosis of acute liver failure associated with echovirus 25 due to immunological similarities to hepatitis A virus and prozone effect

J Clin Microbiol. 2015 Jan;53(1):309-10. doi: 10.1128/JCM.02724-14. Epub 2014 Oct 29.

Authors

Susan K Wollersheim¹, Romney M Humphries², James D Cherry¹, Paul Krogstad³

Affiliations

¹ Department of Pediatrics, Division of Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
² Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
³ Department of Pediatrics, Division of Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, California, USA [email protected].

Abstract

We describe a case of acute liver failure caused by echovirus 25 (E25) in a previously healthy 2-year-old boy. Initial serological studies were consistent with hepatitis A virus (HAV), with prozone phenomenon. The similarity of E25 to HAV may obscure accurate diagnosis in some cases of hepatitis.

Publication types

Case Reports
Research Support, N.I.H., Extramural

MeSH terms

Child, Preschool
Diagnostic Errors*
Echovirus Infections* / diagnosis
Echovirus Infections* / virology
Enterovirus B, Human* / immunology
Enterovirus B, Human* / isolation & purification
Hepatitis A virus / immunology*
Humans
Immunoassay
Liver Failure, Acute* / diagnosis
Liver Failure, Acute* / virology
Male
Serologic Tests

Grants and funding

T32 AI089398/AI/NIAID NIH HHS/United States