Simultaneous detection of herpes simplex virus 1 and 2 in the cerebrospinal fluid of a patient with seizures and encephalitis

Neil W Anderson; William Sistrunk; Matthew J Binnicker

doi:10.1128/JCM.02718-14

Simultaneous detection of herpes simplex virus 1 and 2 in the cerebrospinal fluid of a patient with seizures and encephalitis

J Clin Microbiol. 2015 Jan;53(1):343-5. doi: 10.1128/JCM.02718-14. Epub 2014 Oct 29.

Authors

Neil W Anderson¹, William Sistrunk², Matthew J Binnicker³

Affiliations

¹ Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
² Division of Infectious Diseases, Mercy Clinic, Springfield, Missouri, USA.
³ Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA [email protected].

Abstract

We report a case of a 62-year-old female with seizures and encephalitis. Molecular testing of the patient's cerebrospinal fluid was positive for both herpes simplex virus 1 and 2 (HSV-1 and HSV-2). To our knowledge, this is the first report of simultaneous detection of HSV-1 and HSV-2 in cerebrospinal fluid.

Publication types

Case Reports

MeSH terms

Acyclovir / therapeutic use
Antiviral Agents / therapeutic use
DNA, Viral / cerebrospinal fluid*
Encephalitis*
Female
Herpes Simplex* / cerebrospinal fluid
Herpes Simplex* / complications
Herpes Simplex* / virology
Herpesvirus 1, Human / genetics*
Herpesvirus 2, Human / genetics*
Humans
Middle Aged
Seizures*

Substances

Antiviral Agents
DNA, Viral
Acyclovir