Emergence of Citrobacter freundii carrying IMP-8 metallo-β-lactamase in Germany

S Peter; C Wolz; M Kaase; M Marschal; B Schulte; W Vogel; I Autenrieth; M Willmann

doi:10.1002/nmi2.36

Emergence of Citrobacter freundii carrying IMP-8 metallo-β-lactamase in Germany

New Microbes New Infect. 2014 Mar;2(2):42-5. doi: 10.1002/nmi2.36. Epub 2014 Mar 20.

Authors

S Peter¹, C Wolz¹, M Kaase², M Marschal¹, B Schulte¹, W Vogel³, I Autenrieth¹, M Willmann¹

Affiliations

¹ Institute of Medical Microbiology and Hygiene, University of Tübingen Tübingen, Germany ; German Centre for Infection Research (DZIF), partner site Tübingen Tübingen, Germany.
² National Reference Laboratory for Multidrug Resistant Gram-negative Bacteria, Department of Medical Microbiology, Ruhr University Bochum Bochum, Germany.
³ Medical Centre, Department of Haematology, Oncology, Immunology, Rheumatology and Pulmonology, University of Tübingen Tübingen, Germany.

PMID: 25356340
PMCID: PMC4184589
DOI: 10.1002/nmi2.36

Abstract

Metallo-β-lactamases (MBLs) in Enterobacteriaceae are an increasing problem worldwide. This report describes the isolation of Citrobacter freundii carrying IMP-8 MBL from three patients during the period from March 2012 until March 2013 in Germany. The bla IMP-8 enzyme is predominantly found in Asia, where IMP-8 has spread to various enterobacterial species causing serious infections. To our best knowledge, this is the first report of bla IMP-8 habouring Enterobacteriaceae in Europe.

Keywords: Antimicrobial resistance; IMP; infection control; laboratory surveillance; metallo-β-lactamases; multidrug resistance.