Exercise, neurotrophins, and axon regeneration in the PNS

Physiology (Bethesda). 2014 Nov;29(6):437-45. doi: 10.1152/physiol.00028.2014.

Abstract

Electrical stimulation and exercise are treatments to enhance recovery from peripheral nerve injuries. Brain-derived neurotrophic factor and androgen receptor signaling are requirements for the effectiveness of these treatments. Increased neuronal activity is adequate to promote regeneration in injured nerves, but the dosing of activity and its relationship to neurotrophins and sex steroid hormones is less clear. Translation of these therapies will require principles associated with their cellular mechanisms.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Axons* / metabolism
  • Axons* / pathology
  • Electric Stimulation Therapy*
  • Exercise Therapy*
  • Female
  • Gonadal Steroid Hormones / metabolism
  • Humans
  • Male
  • Nerve Growth Factors / metabolism*
  • Nerve Regeneration*
  • Peripheral Nerve Injuries / diagnosis
  • Peripheral Nerve Injuries / metabolism
  • Peripheral Nerve Injuries / physiopathology
  • Peripheral Nerve Injuries / therapy*
  • Peripheral Nerves / metabolism
  • Peripheral Nerves / pathology
  • Peripheral Nerves / physiopathology*
  • Recovery of Function
  • Signal Transduction
  • Treatment Outcome

Substances

  • Gonadal Steroid Hormones
  • Nerve Growth Factors