Multigenerational chromatin marks: no enzymes need apply

William G Kelly

doi:10.1016/j.devcel.2014.10.008

Multigenerational chromatin marks: no enzymes need apply

Dev Cell. 2014 Oct 27;31(2):142-4. doi: 10.1016/j.devcel.2014.10.008.

Author

William G Kelly¹

Affiliation

¹ Biology Department, Emory University, Atlanta, GA 30322, USA. Electronic address: [email protected].

PMID: 25373774
DOI: 10.1016/j.devcel.2014.10.008

Abstract

Epigenetic memory stably maintains and transmits information during genome replication. Recently in Science, Gaydos et al. (2014) show that repressive chromatin marks exhibit transgenerational stability in the absence of chromatin-modifying enzymes in Caenorhabditis elegans, in contrast to work in flies suggesting that such proteins mediate stable inheritance of epigenetic modifications.

Publication types

Comment

MeSH terms

Animals
Caenorhabditis elegans / embryology*
Caenorhabditis elegans / genetics*
Caenorhabditis elegans Proteins / antagonists & inhibitors*
Caenorhabditis elegans Proteins / metabolism*
DNA Methylation*
Epigenesis, Genetic*
Gene Expression Regulation, Developmental*
Germ Cells / metabolism*
Histone Demethylases / metabolism*
Male
Polycomb Repressive Complex 2 / antagonists & inhibitors*
Polycomb Repressive Complex 2 / metabolism*
X Chromosome / genetics*

Substances

Caenorhabditis elegans Proteins
Histone Demethylases
Polycomb Repressive Complex 2