A germ line mutation in cathepsin B points toward a role in asparaginase pharmacokinetics

Blood. 2014 Nov 6;124(19):3027-9. doi: 10.1182/blood-2014-06-582627.
No abstract available

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / pharmacokinetics
  • Asparaginase / pharmacokinetics*
  • Cathepsin B / genetics*
  • Child
  • Drug Monitoring / methods
  • Female
  • Germ-Line Mutation*
  • Humans
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*

Substances

  • Antineoplastic Agents
  • CTSB protein, human
  • Cathepsin B
  • Asparaginase