Central nervous system cryptococcoma in a Ugandan patient with Human Immunodeficiency Virus

Sruti S Velamakanni; Nathan C Bahr; Abdu K Musubire; David R Boulware; Joshua Rhein; Henry W Nabeta

doi:10.1016/j.mmcr.2014.08.003

Central nervous system cryptococcoma in a Ugandan patient with Human Immunodeficiency Virus

Med Mycol Case Rep. 2014 Aug 11:6:10-3. doi: 10.1016/j.mmcr.2014.08.003. eCollection 2014 Oct.

Authors

Sruti S Velamakanni¹, Nathan C Bahr², Abdu K Musubire³, David R Boulware⁴, Joshua Rhein², Henry W Nabeta³

Affiliations

¹ Infectious Disease Institute, Makerere University, Kampala, Uganda ; Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
² Infectious Disease Institute, Makerere University, Kampala, Uganda ; Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA ; Center for Infectious Diseases & Microbiology Translational Research, University of Minnesota, Minneapolis, MN, USA.
³ Infectious Disease Institute, Makerere University, Kampala, Uganda.
⁴ Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA ; Center for Infectious Diseases & Microbiology Translational Research, University of Minnesota, Minneapolis, MN, USA.

Abstract

Mortality due to AIDS-related Cryptococcal meningitis (CM) is often >50% in low-middle income countries. Dissemination of CM can result in intracranial mass lesions known as cryptococcoma. Patients who develop cryptococcomas often have worse outcomes when compared to patients with cryptococcosis without cryptococcoma. We describe a cryptococcoma in the central nervous system (CNS) in a Ugandan patient with AIDS, and review the diagnosis and management with special focus on difficulties encountered in low or middle-income countries.

Keywords: Central nervous system; Cryptococcoma; Cryptococcus meningitis; Human Immunodeficiency Virus; Immunosuppressed Host.

Abstract

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