Human papillomavirus-related verrucous carcinoma in a renal transplant patient after long-term immunosuppression: a case report

Transplant Proc. 2014 Oct;46(8):2916-9. doi: 10.1016/j.transproceed.2014.09.054.

Abstract

Background: Verrucous carcinoma is a slow-growing tumor with 3 main localizations: Oral cavity, ano-urogenital region, and plantar surface of the foot. On the sole it may rise adjacent to viral warts and very often is mistaken for the common verruca plantaris. Although both conditions-viral warts and cutaneous squamous cell carcinoma-are often diagnosed in immunosuppressed patients, in literature we have found only 3 case reports of verrucous carcinoma in organ transplant recipients.

Case report: We present a case of 26-year-old man after deceased donor renal transplantation with plantar verrucous carcinoma successfully treated with excision and 5% imiquimod.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Alphapapillomavirus*
  • Aminoquinolines / administration & dosage
  • Antineoplastic Agents / administration & dosage
  • Carcinoma, Verrucous / pathology
  • Carcinoma, Verrucous / virology*
  • Foot Diseases / pathology
  • Foot Diseases / virology*
  • Humans
  • Imiquimod
  • Immunocompromised Host*
  • Immunosuppression Therapy / adverse effects
  • Kidney Transplantation*
  • Male
  • Papillomavirus Infections / complications*
  • Skin Neoplasms / pathology
  • Skin Neoplasms / virology*

Substances

  • Aminoquinolines
  • Antineoplastic Agents
  • Imiquimod