A rare case of IGH/MYC and IGH/BCL2 double hit primary plasma cell leukemia

Haematologica. 2015 Feb;100(2):e60-2. doi: 10.3324/haematol.2014.111385. Epub 2014 Nov 7.

Authors

Anna Kalff¹, Tiffany Khong¹, Meaghan Wall², Malgorzata Gorniak³, Sridurga Mithraprabhu¹, Lynda J Campbell², Andrew Spencer⁴

Affiliations

¹ Alfred Hospital, Myeloma Research Group, Australian Centre for Blood Diseases, Monash University, Melbourne.
² Victorian Cancer Cytogenetics Service, St Vincent's Hospital, Melbourne Department of Medicine, University of Melbourne, Melbourne, Australia.
³ Department of Laboratory Haematology, Alfred Hospital, Melbourne, Australia.
⁴ Alfred Hospital, Myeloma Research Group, Australian Centre for Blood Diseases, Monash University, Melbourne [email protected].

No abstract available

Keywords: IGH/MYC; leukemia; primary plasma cell.

Publication types

Case Reports
Letter

MeSH terms

Adult
Biomarkers, Tumor / genetics
Biomarkers, Tumor / metabolism
Fatal Outcome
Female
Flow Cytometry
Humans
Immunoglobulin Heavy Chains / genetics*
In Situ Hybridization, Fluorescence
Leukemia, Plasma Cell / genetics*
Leukemia, Plasma Cell / metabolism
Leukemia, Plasma Cell / pathology
Oncogene Proteins, Fusion / genetics*
Proto-Oncogene Proteins c-bcl-2 / genetics*
Proto-Oncogene Proteins c-myc / genetics*
Translocation, Genetic / genetics*

Substances

BCL2 protein, human
Biomarkers, Tumor
Immunoglobulin Heavy Chains
MYC protein, human
Oncogene Proteins, Fusion
Proto-Oncogene Proteins c-bcl-2
Proto-Oncogene Proteins c-myc