Synthesis and characterization of a library of in-situ curing, nonswelling ethoxylated polyol thiol-ene hydrogels for tailorable macromolecule delivery

Adv Mater. 2015 Jan 7;27(1):65-72. doi: 10.1002/adma.201403724. Epub 2014 Nov 10.

Abstract

A transesterfication reaction is used to synthesize tri-thiol-functionalized-ethoxylated polyols that are combined with polyethylene glycol diacrylates to form a biodegradable hydrogel library. Hydrogels display nonswelling equilibration and offer temporal control over material degradation and the release of biomolecules. The demonstrated in vitro biocompatibility makes this a versatile platform that can be used for local drug delivery to volume-constrained anatomical sites.

Keywords: candida antarctica lipase B; drug delivery; hydrogels; polymeric materials; thiol-michael addition.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorbable Implants
  • Animals
  • Biocompatible Materials / chemical synthesis
  • Biocompatible Materials / therapeutic use
  • Cell Line
  • Cell Survival
  • Diffusion
  • Drug Delivery Systems
  • Hydrogels / chemical synthesis*
  • Hydrogels / therapeutic use
  • Kinetics
  • Macromolecular Substances / administration & dosage
  • Macromolecular Substances / pharmacokinetics
  • Materials Testing
  • Permeability
  • Polyethylene Glycols / chemistry
  • Polymers / chemical synthesis
  • Polymers / therapeutic use
  • Temperature
  • Tissue Scaffolds

Substances

  • Biocompatible Materials
  • Hydrogels
  • Macromolecular Substances
  • Polymers
  • poly(ethylene glycol)diacrylate
  • polyol
  • Polyethylene Glycols