Lack of association between BDNF Val66Met gene polymorphism and late-onset depression in a Chinese Han population

Jiayong You; Yonggui Yuan; Yanyan Shi; Zhijun Zhang; Xiangrong Zhang; Hailin Li

doi:10.1111/j.1601-5215.2009.00401.x

Lack of association between BDNF Val66Met gene polymorphism and late-onset depression in a Chinese Han population

Acta Neuropsychiatr. 2009 Aug;21(4):186-90. doi: 10.1111/j.1601-5215.2009.00401.x.

Authors

Jiayong You¹, Yonggui Yuan¹, Yanyan Shi¹, Zhijun Zhang², Xiangrong Zhang¹, Hailin Li¹

Affiliations

¹ 1Department of Psychiatry, Nanjing Brain Hospital affiliated to Nanjing Medical University, Nanjing, 210029, China.
² 2Department of Neuropsychiatry, Affiliated ZhongDa Hospital of Southeast University, Nanjing, 210009, China.

PMID: 25384632
DOI: 10.1111/j.1601-5215.2009.00401.x

Abstract

Background: Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene has been suggested to be associated with major depressive disorder (MDD). There were a few reports of the relationship between the variant and late-onset depression (LOD) in Chinese Han population.

Objective: To investigate the relationship among BDNF Val66Met gene variants, BDNF plasma level and LOD.

Methods: Chinese Han patients with LOD (n = 99) and control subjects (n = 110) were assessed for BDNF Val66Met gene polymorphism. BDNF plasma level was tested only in LOD.

Results: There were no significant differences in genotypes and allele frequencies between cases and controls (p = 0.744 and p = 0.845, respectively). Plasma BDNF level also did not show significant differences in three genotypes in LOD (p = 0.860).

Conclusion: The Val66Met polymorphism in BDNF gene may not confer susceptibility to LOD in Chinese Han population.