[Sickle cell disease: pneumococcus escapes prevention and adapts to the disease. Consequences on vaccine design]

MeSH terms

• Adaptation, Physiological / genetics
• Adaptation, Physiological / immunology
• Anemia, Sickle Cell / complications*
• Anemia, Sickle Cell / metabolism
• Anemia, Sickle Cell / microbiology
• Animals
• Antibiotic Prophylaxis
• Bacterial Proteins / genetics
• Bacterial Proteins / immunology
• Biological Transport / genetics
• Carrier State / microbiology
• Child, Preschool
• Complement System Proteins / deficiency
• Disease Models, Animal
• Drug Design
• Drug Resistance, Multiple, Bacterial / genetics
• Genetic Predisposition to Disease
• Host-Pathogen Interactions* / genetics
• Host-Pathogen Interactions* / immunology
• Humans
• Infant
• Iron / blood
• Metabolome
• Mice
• Nasopharynx / microbiology
• Penicillin Resistance / genetics
• Pneumococcal Infections / complications*
• Pneumococcal Infections / genetics
• Pneumococcal Infections / microbiology
• Pneumococcal Infections / prevention & control
• Pneumococcal Vaccines* / immunology
• Polysaccharides, Bacterial / genetics
• Polysaccharides, Bacterial / immunology
• Selection, Genetic*
• Streptococcus pneumoniae / classification
• Streptococcus pneumoniae / genetics
• Streptococcus pneumoniae / immunology
• Streptococcus pneumoniae / pathogenicity*
• Virulence