Genome Sequence of the Anterograde-Spread-Defective Herpes Simplex Virus 1 Strain MacIntyre

Moriah L Szpara; Yolanda R Tafuri; Lance Parsons; Jacob T Shreve; Esteban A Engel; L W Enquist

doi:10.1128/genomeA.01161-14

Genome Sequence of the Anterograde-Spread-Defective Herpes Simplex Virus 1 Strain MacIntyre

Genome Announc. 2014 Nov 13;2(6):e01161-14. doi: 10.1128/genomeA.01161-14.

Authors

Moriah L Szpara¹, Yolanda R Tafuri², Lance Parsons³, Jacob T Shreve⁴, Esteban A Engel², L W Enquist

Affiliations

¹ [email protected].
² Department of Molecular Biology, the Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey, USA.
³ Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA.
⁴ Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA.

Abstract

We used paired-end Illumina deep sequencing and de novo assembly to determine the genome sequence of herpes simplex virus 1 (HSV-1) strain MacIntyre (aka McIntyre). The MacIntyre strain originated from the brain of a patient with lethal HSV encephalitis and has a unique limitation in its neuronal spread, moving solely in the retrograde direction.

Abstract

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