Intrathecal overproduction of proinflammatory cytokines and chemokines in febrile infection-related refractory status epilepticus

J Neurol Neurosurg Psychiatry. 2015 Jul;86(7):820-2. doi: 10.1136/jnnp-2014-309388. Epub 2014 Nov 14.

Authors

Hiroshi Sakuma¹, Naoyuki Tanuma², Ichiro Kuki³, Yukitoshi Takahashi⁴, Masashi Shiomi⁵, Masaharu Hayashi¹

Affiliations

¹ Department of Brain Development and Neural Regeneration, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
² Department of Brain Development and Neural Regeneration, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan Department of Pediatrics, Tokyo Metropolitan Fuchu Medical Center for the Disabled, Tokyo, Japan.
³ Department of Child Neurology, Osaka City General Hospital, Osaka, Japan.
⁴ National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorder, Shizuoka, Japan.
⁵ Department of Pediatrics, Aizenbashi Hospital, Osaka, Japan.

PMID: 25398790
DOI: 10.1136/jnnp-2014-309388

No abstract available

Keywords: EPILEPSY.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Chemokine CXCL10 / blood
Chemokine CXCL10 / cerebrospinal fluid
Chemokine CXCL10 / physiology
Chemokines / blood
Chemokines / cerebrospinal fluid
Chemokines / physiology*
Child
Child, Preschool
Cytokines / blood
Cytokines / cerebrospinal fluid
Cytokines / physiology*
Female
Humans
Infant
Interleukin-6 / blood
Interleukin-6 / cerebrospinal fluid
Interleukin-6 / physiology
Interleukin-8 / blood
Interleukin-8 / cerebrospinal fluid
Interleukin-8 / physiology
Male
Seizures, Febrile / blood
Seizures, Febrile / cerebrospinal fluid
Seizures, Febrile / complications*
Seizures, Febrile / physiopathology
Status Epilepticus / blood
Status Epilepticus / cerebrospinal fluid
Status Epilepticus / etiology*
Status Epilepticus / physiopathology

Substances

CXCL10 protein, human
Chemokine CXCL10
Chemokines
Cytokines
Interleukin-6
Interleukin-8