Efficient delivery of therapeutic miRNA nanocapsules for tumor suppression

Adv Mater. 2015 Jan 14;27(2):292-7. doi: 10.1002/adma.201403387. Epub 2014 Nov 14.

Abstract

miRNA nanocapsules are synthesized with enhanced stability for miRNA delivery with high transduction efficiency, offering a novel class of miRNA vectors for cancer therapy.

Keywords: angiogenesis; cancer therapy; miR-21; miRNA delivery; nanocapsules.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylamide / chemistry
  • Animals
  • Cell Line, Tumor
  • Cell Survival
  • Gene Knockdown Techniques
  • Genetic Therapy / instrumentation*
  • Genetic Therapy / methods*
  • Human Umbilical Vein Endothelial Cells
  • Humans
  • Kinetics
  • Methacrylates / chemistry
  • Mice, Inbred BALB C
  • Mice, Nude
  • MicroRNAs / genetics
  • MicroRNAs / metabolism
  • MicroRNAs / therapeutic use*
  • Nanocapsules / therapeutic use*
  • Neoplasm Transplantation
  • Neoplasms / physiopathology
  • Neoplasms / therapy*
  • Polymerization
  • RNA, Antisense / metabolism
  • RNA, Antisense / therapeutic use
  • Transduction, Genetic

Substances

  • MIRN21 microRNA, human
  • Methacrylates
  • MicroRNAs
  • Nanocapsules
  • RNA, Antisense
  • Acrylamide
  • ethylene dimethacrylate