Resolution enhancement in coherent x-ray diffraction imaging by overcoming instrumental noise

Opt Express. 2014 Nov 17;22(23):29161-9. doi: 10.1364/OE.22.029161.

Abstract

We report that reference objects, strong scatterers neighboring weak phase objects, enhance the phase retrieval and spatial resolution in coherent x-ray diffraction imaging (CDI). A CDI experiment with Au nano-particles exhibited that the reference objects amplified the signal-to-noise ratio in the diffraction intensity at large diffraction angles, which significantly enhanced the image resolution. The interference between the diffracted x-ray from reference objects and a specimen also improved the retrieval of the phase of the diffraction signal. The enhancement was applied to image NiO nano-particles and a mitochondrion and confirmed in a simulation with a bacteria phantom. We expect that the proposed method will be of great help in imaging weakly scattering soft matters using coherent x-ray sources including x-ray free electron lasers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Diagnostic Imaging*
  • Image Enhancement / methods*
  • Phantoms, Imaging*
  • Signal-To-Noise Ratio
  • X-Ray Diffraction / methods*