The effect of CH 402 dihydroquinoline type antioxidant on the activity of Na+-K+-ATP-ase and Mg++-ATP-ase of rat brain subcellular fractions in the presence and absence of ascorbic acid

A Blázovics; A Somogyi; D Ambrus; D Mathiász; A Vereckei; J Fehér

The effect of CH 402 dihydroquinoline type antioxidant on the activity of Na+-K+-ATP-ase and Mg++-ATP-ase of rat brain subcellular fractions in the presence and absence of ascorbic acid

Acta Physiol Hung. 1989;73(1):3-7.

Authors

A Blázovics¹, A Somogyi, D Ambrus, D Mathiász, A Vereckei, J Fehér

Affiliation

¹ Second Department of Medicine, Semmelweis Medical University, Budapest, Hungary.

PMID: 2540618

Abstract

Authors studied the activities of Na+-K+-ATP-ase and Mg++-ATP-ase as indicators of lipid peroxidation on rat brain plasmamembrane and microsomal fraction. The CH 402 (Sodium(2,2-dimethyl-1,2-dihydroquinoline-4-yl)methane sulfonate) a synthetic, water soluble, non toxic dihydroquinoline type antioxidant proved to be effective in decreasing the membrane damage caused by ascorbic acid induced lipid peroxidation. The CH 402 did not inhibit the Na+-K+-ATP-ase and Mg++-ATP-ase activities even at a concentration of 10(-3) mol/l.

MeSH terms

Animals
Antioxidants / pharmacology*
Ascorbic Acid / pharmacology*
Brain / drug effects
Brain / enzymology*
Ca(2+) Mg(2+)-ATPase / metabolism*
Dose-Response Relationship, Drug
Hydroxyquinolines / administration & dosage
Hydroxyquinolines / pharmacology*
Lipid Peroxidation / drug effects
Male
Rats
Rats, Inbred Strains
Sodium-Potassium-Exchanging ATPase / metabolism*
Subcellular Fractions / drug effects
Subcellular Fractions / enzymology
Time Factors

Substances

Antioxidants
Hydroxyquinolines
Ca(2+) Mg(2+)-ATPase
Sodium-Potassium-Exchanging ATPase
Ascorbic Acid