Abstract
This study was focused on the analysis of the phenolic content, antioxidant, antibacterial, anti-cholinesterase, anti-tyrosinase, anti-amylase and anti-glucosidase activity of three solvent extracts from Cotoneaster nummularia. Moreover, water extract was tested in terms of mutagenic/anti-mutagenic effects. The antioxidant activities of these extracts were evaluated by DPPH, ABTS, O2, metal chelating, phosphomolybdenum, β-carotene/linoleic acid, ferric and cupric reducing power assays. Enzyme inhibitory activities were also examined with colorimetric methods. Generally, methanol and water extracts exhibited excellent biological activities. These extracts were rich in phenolic and flavonoid content. Furthermore, Cotoneaster extracts indicated appreciable antibacterial properties against human pathogen strains. HPLC analysis showed that ferulic acid, chlorogenic acid, (-) - epicatechin and (+)-catechin were the major phenolics in extracts tested. These data offer that these extracts from C. nummularia may be considered as a potential source of biological agents for developing functional foods or drug formulations.
MeSH terms
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Acetates / chemistry
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology
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Antimutagenic Agents / chemistry
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Antimutagenic Agents / isolation & purification
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Antimutagenic Agents / pharmacology
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Antioxidants / chemistry
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Antioxidants / isolation & purification
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Chemistry, Pharmaceutical
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Chromatography, High Pressure Liquid
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / metabolism
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Enzymes / chemistry
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Enzymes / metabolism
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Flavonoids / analysis
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Flavonoids / chemistry
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Flavonoids / pharmacology
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Functional Food
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Gram-Negative Bacteria / drug effects
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Gram-Negative Bacteria / isolation & purification
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Gram-Positive Bacteria / drug effects
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Gram-Positive Bacteria / isolation & purification
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Humans
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Methanol / chemistry
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Microbial Sensitivity Tests
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Mutagenicity Tests
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Phenols / analysis
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Phenols / chemistry
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Phenols / pharmacology
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Plant Extracts / chemistry*
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Plant Extracts / pharmacology
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Protein Binding
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Rosaceae / chemistry*
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Rosaceae / metabolism
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Salmonella typhimurium / drug effects
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Salmonella typhimurium / genetics
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Water / chemistry
Substances
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Acetates
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Anti-Bacterial Agents
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Antimutagenic Agents
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Antioxidants
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Enzyme Inhibitors
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Enzymes
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Flavonoids
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Phenols
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Plant Extracts
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Water
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ethyl acetate
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Methanol
Grants and funding
The authors have no funding or support to report.