Co-Morbidity Part 2 - Neurobiology and Suicide Risk; Modelling the consequences of Bipolar and Anxiety Co-Morbidity

Mark Agius; Norma Verdolini; Francesca Falzon Aquilina; Sophie Butler

Co-Morbidity Part 2 - Neurobiology and Suicide Risk; Modelling the consequences of Bipolar and Anxiety Co-Morbidity

Psychiatr Danub. 2014 Nov:26 Suppl 1:336-9.

Authors

Mark Agius¹, Norma Verdolini, Francesca Falzon Aquilina, Sophie Butler

Affiliation

¹ SEPT at Weller Wing, Bedford Hospital, Bedford, Bedfordshire, MK42 9DJ, UK, [email protected].

PMID: 25413561

Abstract

We review the evidence that Bipolar Disorder with Comorbid Anxiety, Rapid Cycling Bipolar Disorder, Mixed Affective states, are all related to each other and to Dopamine Transmission in Bipolar Disorder. All these states are related to the presence of particular polymorphisms of the genes of the D2 and D3 receptors. All these states increase the risk of suicidality. Substance and alcohol abuse comorbid with bipolar disorder increases the risk of both Rapid Cycling and Suicidality. We present a model which demonstrates these relationships.