Not merely quiescent: telomeres in quiescent HSCs

Blood. 2014 Nov 20;124(22):3179-80. doi: 10.1182/blood-2014-10-603258.

Abstract

In this issue of Blood, Wang et al elegantly show that telomere shortening results in DNA damage that induces apoptosis and senescence in quiescent hematopoietic stem cells (HSCs).

Publication types

  • Comment

MeSH terms

  • Animals
  • Apoptosis / physiology*
  • Cellular Senescence / physiology*
  • Hematopoiesis*
  • Hematopoietic Stem Cells / physiology*
  • Telomere Shortening / physiology*