Primary cutaneous T-cell lymphoma presenting as mycosis fungoides with a T-/null-cell phenotype: report of two cases

L Bekel; G Chaby; C Lok; A Dadban; D Chatelain; S Ingen-Housz-Oro; N Ortonne

doi:10.1111/bjd.13563

Primary cutaneous T-cell lymphoma presenting as mycosis fungoides with a T-/null-cell phenotype: report of two cases

Br J Dermatol. 2015 Jun;172(6):1637-1641. doi: 10.1111/bjd.13563. Epub 2015 Apr 29.

Authors

L Bekel¹, G Chaby¹, C Lok¹, A Dadban¹, D Chatelain², S Ingen-Housz-Oro³, N Ortonne⁴

Affiliations

¹ Department of Dermatology, Hôpital Sud, University of Amiens, 80054, Amiens, France.
² Department of Pathology, Hôpital Nord, University of Amiens, 80054, Amiens, France.
³ Department of Dermatology, Assistance Publique-Hôpitaux de Paris (AP-HP) Groupe Hospitalier Henri Mondor, UPEC University, 94010, Créteil, France.
⁴ Department of Pathology, INSERM U955 Equipe 9, AP-HP, Groupe Hospitalier Henri Mondor, UPEC University, 94010, Créteil, France.

PMID: 25420682
DOI: 10.1111/bjd.13563

Abstract

Variations in the clinical and histological presentation of cutaneous T-cell lymphoma (CTCL) can hamper diagnosis. We report two cases of a novel presentation of CTCL characterized by an aberrant immunophenotype with complete loss of pan T-cell antigens including T-cell receptor β chain and showing the clinical and histopathological appearance of erythrodermic and plaque-stage mycosis fungoides.

Publication types

Case Reports
Review

MeSH terms

Aged
Antigens, Differentiation, T-Lymphocyte / immunology
Diagnosis, Differential
Humans
Lymphoma, T-Cell, Cutaneous / diagnosis*
Lymphoma, T-Cell, Cutaneous / immunology
Male
Middle Aged
Mycosis Fungoides / diagnosis*
Mycosis Fungoides / immunology
Phenotype
Receptors, Antigen, T-Cell, alpha-beta / deficiency
Skin Neoplasms / diagnosis*
Skin Neoplasms / immunology

Substances

Antigens, Differentiation, T-Lymphocyte
Receptors, Antigen, T-Cell, alpha-beta