Abstract
We report an efficient method for the preparation of unprecedented head-to-tail cyclic sulfono-γ-AApeptides. Following this method, a number of cyclic sequences bearing two to five subunits were efficiently synthesized. In addition, the X-ray crystal structure study of a three-membered cyclic sulfono-γ-AApeptide revealed a type II β-turn-like character.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Amino Acids, Sulfur / chemistry*
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Crystallography, X-Ray
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Cyclization
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Molecular Structure
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Peptides, Cyclic / chemical synthesis*
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Peptides, Cyclic / chemistry
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Peptidomimetics / chemical synthesis*
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Peptidomimetics / chemistry
Substances
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Amino Acids, Sulfur
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Peptides, Cyclic
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Peptidomimetics