Abstract
The incubation of isolated rat hepatocytes with vanadate increased the concentration of fructose 2,6-bisphosphate without modifying 6-phosphofructo-2-kinase activity. Vanadate also reverted and prevented the decrease of fructose 2,6-bisphosphate levels, of the "active" form of the 6-phosphofructo 2-kinase and of the pyruvate kinase activity ratio produced by glucagon, by probably counteracting the increase in cyclic AMP concentration.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cyclic AMP / metabolism
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Fasting
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Food
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Fructosediphosphates / metabolism
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Glucagon / pharmacology*
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Kinetics
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Liver / drug effects
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Liver / metabolism*
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Male
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Phosphofructokinase-1 / metabolism
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Phosphorylation
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Pyruvate Kinase / metabolism
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Rats
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Rats, Inbred Strains
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Vanadates / pharmacology*
Substances
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Fructosediphosphates
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Vanadates
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fructose 2,6-diphosphate
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Glucagon
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Cyclic AMP
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Phosphofructokinase-1
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Pyruvate Kinase