Functional assessment of coronary artery disease by intravascular ultrasound and computational fluid dynamics simulation

Sebastián Carrizo; Xinzhou Xie; Rafael Peinado-Peinado; Angel Sánchez-Recalde; Santiago Jiménez-Valero; Guillermo Galeote-Garcia; Raúl Moreno

doi:10.1016/j.repc.2014.03.013

Functional assessment of coronary artery disease by intravascular ultrasound and computational fluid dynamics simulation

Rev Port Cardiol. 2014 Oct;33(10):645.e1-4. doi: 10.1016/j.repc.2014.03.013. Epub 2014 Oct 14.

Authors

Sebastián Carrizo¹, Xinzhou Xie², Rafael Peinado-Peinado³, Angel Sánchez-Recalde⁴, Santiago Jiménez-Valero⁴, Guillermo Galeote-Garcia⁴, Raúl Moreno⁴

Affiliations

¹ Hemodynamics and Interventional Cardiology Unit, Department of Cardiology, University Hospital La Paz, Madrid, Spain. Electronic address: [email protected].
² Medical Ultrasound Lab, Department of Electronic Engineering, Fudan University, Shanghai, China.
³ Electrophysiology and Arrhythmia Unit, Department of Cardiology, University Hospital La Paz, Madrid, Spain.
⁴ Hemodynamics and Interventional Cardiology Unit, Department of Cardiology, University Hospital La Paz, Madrid, Spain.

PMID: 25441999
DOI: 10.1016/j.repc.2014.03.013

Abstract

Clinical trials have shown that functional assessment of coronary stenosis by fractional flow reserve (FFR) improves clinical outcomes. Intravascular ultrasound (IVUS) complements conventional angiography, and is a powerful tool to assess atherosclerotic plaques and to guide percutaneous coronary intervention (PCI). Computational fluid dynamics (CFD) simulation represents a novel method for the functional assessment of coronary flow. A CFD simulation can be calculated from the data normally acquired by IVUS images. A case of coronary heart disease studied with FFR and IVUS, before and after PCI, is presented. A three-dimensional model was constructed based on IVUS images, to which CFD was applied. A discussion of the literature concerning the clinical utility of CFD simulation is provided.

Keywords: Computer simulation; Coronary artery disease; Dinâmica de fluidos; Doença cardíaca coronária; Fluid dynamics; Intravascular ultrasound; Myocardial fractional flow reserve; Reserva fracionada de fluxo miocárdico; Simulação computorizada; Ultra-sonografia intravascular.

Publication types

Case Reports

MeSH terms

Computer Simulation*
Coronary Artery Disease / diagnostic imaging*
Coronary Artery Disease / physiopathology*
Humans
Hydrodynamics*
Male
Middle Aged
Ultrasonography, Interventional*