Abstract
Eleven indole alkaloids, comprising four corynanthean, two eburnane, one aspidofractinine, one secoleuconoxine, one andranginine, and two pauciflorine type alkaloids were isolated from the stem-bark and leaf extracts of Kopsia pauciflora. Their structures were determined using NMR and MS analyses. The catharinensine type alkaloid kopsirensine B and the secoleuconoxine alkaloid arboloscine A showed moderate to weak activity in reversing MDR in vincristine-resistant KB cells. The alkaloid content was markedly different compared to that of a sample from Malaysian Borneo.
Keywords:
Apocynaceae; Indole alkaloids; Kopsia pauciflora; NMR; Reversal of multidrug-resistance.
Copyright © 2014 Elsevier Ltd. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents, Phytogenic / chemistry
-
Antineoplastic Agents, Phytogenic / isolation & purification*
-
Antineoplastic Agents, Phytogenic / pharmacology
-
Apocynaceae / chemistry*
-
Drug Resistance, Multiple / drug effects
-
Drug Resistance, Neoplasm / drug effects
-
Drug Screening Assays, Antitumor
-
Humans
-
Indole Alkaloids / chemistry
-
Indole Alkaloids / isolation & purification*
-
Indole Alkaloids / pharmacology
-
KB Cells
-
Lactams
-
Malaysia
-
Molecular Structure
-
Nuclear Magnetic Resonance, Biomolecular
-
Plant Bark / chemistry
-
Plant Leaves / chemistry
-
Vincristine / pharmacology
Substances
-
Antineoplastic Agents, Phytogenic
-
Indole Alkaloids
-
Lactams
-
andranginine
-
aspidofractinine
-
corynanthean
-
eburnan
-
pauciflorine A
-
pauciflorine B
-
secoleuconoxine
-
Vincristine