Increased plasma incretin concentrations identifies a subset of patients with persistent congenital hyperinsulinism without KATP channel gene defects

J Pediatr. 2015 Jan;166(1):191-4. doi: 10.1016/j.jpeds.2014.09.019. Epub 2014 Oct 23.

Abstract

Congenital hyperinsulinism causes profound hypoglycemia, which may persist or resolve spontaneously. Among 13 children with congenital hyperinsulinism, elevated incretin hormone concentrations were detected in 2 with atypical, persistent disease. We suggest that incretin biomarkers may identify these patients, and that elevated hormone levels may contribute to their pathophysiology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers / blood*
  • Child, Preschool
  • Congenital Hyperinsulinism / blood*
  • Congenital Hyperinsulinism / genetics
  • Humans
  • Incretins / blood*
  • Infant
  • Infant, Newborn
  • KATP Channels / genetics*
  • Mutation
  • United Kingdom

Substances

  • Biomarkers
  • Incretins
  • KATP Channels