Abstract
We report a case of multidrug-resistant (MDR) Acinetobactor baumannii isolates obtained from a traveler returned from Brunei. Whole-genome sequencing analysis revealed that the isolates harbored blaOxA-23 and armA. The minimum inhibitory concentrations of antibiotics against the strain were as follows: imipenem, 32 μg/ml; meropenem, 32 μg/ml; ciprofloxacin, 16 μg/ml; amikacin, ≧ 1024 μg/ml; arbekacin, ≧ 1024 μg/ml; aztreonam, 64 μg/ml; colistin, 4 μg/ml. A. baumannii harboring both blaOxA-23 and armA is rarely reported in Japan, and, to the best of our knowledge, this is the second report of A. baumannii harboring both resistant genes in Japan.
Keywords:
16S rRNA methylase; Acinetobacter baumannii; Antimicrobial resistance; Carbapenemase; armA; bla(OxA-23).
Copyright © 2014. Published by Elsevier Ltd.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Acinetobacter Infections / diagnosis
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Acinetobacter Infections / drug therapy
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Acinetobacter Infections / microbiology*
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Acinetobacter baumannii / enzymology
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Acinetobacter baumannii / isolation & purification*
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Aged
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / therapeutic use
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Bacteremia / diagnosis
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Bacteremia / drug therapy
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Bacteremia / microbiology*
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Bacterial Proteins / metabolism
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Brunei / epidemiology
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Drug Resistance, Multiple, Bacterial*
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Humans
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Male
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Methyltransferases / metabolism
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Microbial Sensitivity Tests
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Pneumonia, Bacterial / diagnosis
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Pneumonia, Bacterial / drug therapy
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Pneumonia, Bacterial / microbiology*
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Travel*
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beta-Lactamases / metabolism
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Methyltransferases
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beta-Lactamases
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beta-lactamase OXA-23, Acinetobacter baumannii