Comprehensive summary--Predict-IV: A systems toxicology approach to improve pharmaceutical drug safety testing

Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):4-6. doi: 10.1016/j.tiv.2014.09.016. Epub 2014 Oct 29.

Abstract

This special issue of Toxicology in Vitro is dedicated to disseminating the results of the EU-funded collaborative project "Profiling the toxicity of new drugs: a non animal-based approach integrating toxicodynamics and biokinetics" (Predict-IV; Grant 202222). The project's overall aim was to develop strategies to improve the assessment of drug safety in the early stage of development and late discovery phase, by an intelligent combination of non animal-based test systems, cell biology, mechanistic toxicology and in silico modeling, in a rapid and cost effective manner. This overview introduces the scope and overall achievements of Predict-IV.

Keywords: Cellular models; Central nervous system (CNS); Kidney; Liver; Predict-IV; Systems toxicology.

Publication types

  • Introductory Journal Article
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Culture Techniques / methods*
  • Drug Discovery
  • Drug-Related Side Effects and Adverse Reactions*
  • European Union
  • Humans
  • Models, Biological
  • No-Observed-Adverse-Effect Level
  • Pharmaceutical Preparations / standards*
  • Systems Biology / methods*
  • Toxicity Tests
  • Toxicology / methods*

Substances

  • Pharmaceutical Preparations