Links between osteoarthritis and diabetes: implications for management from a physical activity perspective

Sara R Piva; Allyn M Susko; Samannaaz S Khoja; Deborah A Josbeno; G Kelley Fitzgerald; Frederico G S Toledo

doi:10.1016/j.cger.2014.08.019

Links between osteoarthritis and diabetes: implications for management from a physical activity perspective

Clin Geriatr Med. 2015 Feb;31(1):67-87, viii. doi: 10.1016/j.cger.2014.08.019. Epub 2014 Oct 7.

Authors

Sara R Piva¹, Allyn M Susko², Samannaaz S Khoja², Deborah A Josbeno², G Kelley Fitzgerald², Frederico G S Toledo³

Affiliations

¹ Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Bridgeside Point 1, 100 Technology Drive, Suite 210, Pittsburgh, PA 15219, USA. Electronic address: [email protected].
² Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Bridgeside Point 1, 100 Technology Drive, Suite 210, Pittsburgh, PA 15219, USA.
³ Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, 200 Lothrop Street, BST E1140, Pittsburgh, PA 15261, USA.

Abstract

Osteoarthritis (OA) and type 2 diabetes mellitus (T2DM) often coexist in older adults. Those with T2DM are more susceptible to developing arthritis, which has been traditionally attributed to common risk factors, namely, age and obesity. Alterations in lipid metabolism and hyperglycemia might directly impact cartilage health and subchondral bone, contributing to the development/progression of OA. Adequate management of older persons with both conditions benefits from a comprehensive understanding of the associated risk factors. We discuss common risk factors and emerging links between OA and T2DM, emphasizing the importance of physical activity and the implications of safe and effective physical activity.

Keywords: Arthritis; Exercise; Glucose metabolism; Osteoarthritis; Physical activity; Risk factors; Type 2 diabetes.

Publication types

Review

MeSH terms

Age Factors
Aged
Diabetes Mellitus, Type 2 / complications*
Diabetes Mellitus, Type 2 / therapy*
Exercise*
Humans
Obesity / complications
Osteoarthritis / complications*
Osteoarthritis / therapy*
Risk Factors

Abstract

Publication types

MeSH terms

Grants and funding