3D reconstitution of the patterned neural tube from embryonic stem cells

Stem Cell Reports. 2014 Dec 9;3(6):987-99. doi: 10.1016/j.stemcr.2014.09.020. Epub 2014 Oct 30.

Abstract

Inducing organogenesis in 3D culture is an important aspect of stem cell research. Anterior neural structures have been produced from large embryonic stem cell (ESC) aggregates, but the steps involved in patterning such complex structures have been ill defined, as embryoid bodies typically contained many cell types. Here we show that single mouse ESCs directly embedded in Matrigel or defined synthetic matrices under neural induction conditions can clonally form neuroepithelial cysts containing a single lumen in 3D. Untreated cysts were uniformly dorsal and could be ventralized to floor plate (FP). Retinoic acid posteriorized cysts to cervical levels and induced localize FP formation yielding full patterning along the dorsal/ventral (DV) axis. Correct spatial organization of motor neurons, interneurons, and dorsal interneurons along the DV axis was observed. This system serves as a valuable tool for studying morphogen action in 3D and as a source of patterned spinal cord tissue.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biomarkers
  • Body Patterning / drug effects
  • Body Patterning / genetics
  • Cell Differentiation / drug effects
  • Embryonic Development / drug effects
  • Embryonic Development / genetics
  • Embryonic Stem Cells / cytology*
  • Embryonic Stem Cells / drug effects
  • Embryonic Stem Cells / metabolism
  • Gene Expression
  • Hedgehog Proteins / genetics
  • Mice
  • Neural Tube / cytology*
  • Neural Tube / physiology*
  • Organogenesis* / drug effects
  • Organogenesis* / genetics
  • Tissue Culture Techniques
  • Tretinoin / pharmacology

Substances

  • Biomarkers
  • Hedgehog Proteins
  • Tretinoin