Current management and long-term outcomes following chorioamnionitis

Clark T Johnson; Azadeh Farzin; Irina Burd

doi:10.1016/j.ogc.2014.08.007

Current management and long-term outcomes following chorioamnionitis

Obstet Gynecol Clin North Am. 2014 Dec;41(4):649-69. doi: 10.1016/j.ogc.2014.08.007. Epub 2014 Nov 20.

Authors

Clark T Johnson¹, Azadeh Farzin², Irina Burd³

Affiliations

¹ Department of Gynecology and Obstetrics, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Phipps 228, Baltimore, MD 21287, USA; Integrated Research Center for Fetal Medicine, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Phipps 217, Baltimore, MD 21287, USA.
² Integrated Research Center for Fetal Medicine, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Phipps 217, Baltimore, MD 21287, USA; Department of Pediatrics, Johns Hopkins Medical Institutions, 1800 Orleans Street, Baltimore, MD 21287, USA; International Center for Maternal & Newborn Health, Johns Hopkins University, 605 North Wolfe Street, Baltimore, MD 21287, USA.
³ Department of Gynecology and Obstetrics, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Phipps 228, Baltimore, MD 21287, USA; Integrated Research Center for Fetal Medicine, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Phipps 217, Baltimore, MD 21287, USA; Department of Neurology, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Baltimore, MD 21287, USA. Electronic address: [email protected].

Abstract

Chorioamnionitis is the process of active infection within the amniotic cavity that induces an inflammatory response. A wide variety of pathologic organisms can cause chorioamnionitis. Prompt diagnosis and timely treatment with broad-spectrum antibiotics can help avert the significant short-term and long-term consequences that may result. This review aims to summarize the up-to-date diagnosis criteria, treatment protocols, and long-term sequelae of missed diagnoses or poorly treated disease. It also calls for future studies that aim to better understand the mechanism of disease and to develop better detection and intervention methods to prevent the significant associated morbidity.

Keywords: Chorioamnionitis; Endometritis; Fetal infection; Fetal inflammation; Funisitis; Neonatal sepsis; Perinatal infection; Perinatal inflammation.

Publication types

Review

MeSH terms

Adult
Amniotic Fluid / microbiology*
Anti-Bacterial Agents / therapeutic use*
Chorioamnionitis* / diagnosis
Chorioamnionitis* / drug therapy
Chorioamnionitis* / epidemiology
Chorioamnionitis* / microbiology
Delivery, Obstetric
Drug Administration Schedule
Early Diagnosis
Female
Humans
Infant, Newborn
Practice Guidelines as Topic
Pregnancy
Pregnancy Complications, Infectious* / diagnosis
Pregnancy Complications, Infectious* / drug therapy
Pregnancy Complications, Infectious* / epidemiology
Pregnancy Complications, Infectious* / microbiology
Risk Factors
Sepsis / diagnosis*
Sepsis / drug therapy
Sepsis / epidemiology
Treatment Outcome
United States / epidemiology

Substances

Anti-Bacterial Agents

Grants and funding

K08 HD073315/HD/NICHD NIH HHS/United States