A dual vaccine against influenza & Alzheimer's disease failed to enhance anti-β-amyloid antibody responses in mice with pre-existing virus specific memory

J Neuroimmunol. 2014 Dec 15;277(1-2):77-84. doi: 10.1016/j.jneuroim.2014.10.002. Epub 2014 Oct 16.

Abstract

Novel dual vaccine, WSN-Aβ(1-10), based on the recombinant influenza virus, expressing immunodominant B-cell epitope of β-amyloid, simultaneously induced therapeutically potent anti-Aβ and anti-influenza antibodies. In this study we showed that boosting of WSN-WT primed mice with WSN-Aβ(1-10) enhances anti-viral, but fails to induce anti-Aβ antibody responses. This inhibition is associated with expression of Aβ(1-10) within the context of an inactivated influenza virus vaccine. These results demonstrate that the use of an inactivated influenza virus as a carrier for AD vaccine may not be applicable due to the possible inhibition of anti-Aβ antibody response in individuals previously vaccinated or infected with influenza.

Keywords: Alzheimer's disease; Dual vaccine; Immune responses; Influenza; Memory T cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease* / chemically induced
  • Alzheimer Disease* / immunology
  • Alzheimer Disease* / prevention & control
  • Alzheimer Vaccines / immunology
  • Alzheimer Vaccines / therapeutic use*
  • Amyloid beta-Peptides / immunology*
  • Amyloid beta-Peptides / toxicity
  • Analysis of Variance
  • Animals
  • Antibodies / blood
  • Disease Models, Animal
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Flow Cytometry
  • Hemagglutination Inhibition Tests
  • Humans
  • Influenza, Human / immunology*
  • Influenza, Human / virology
  • Lymphocyte Activation
  • Lymphocytes / immunology*
  • Mice
  • Mice, Inbred C57BL
  • T-Lymphocytes, Regulatory

Substances

  • Alzheimer Vaccines
  • Amyloid beta-Peptides
  • Antibodies