MRI negative meningeal myeloma with abducens nerve palsies responding to intrathecal chemotherapy

A Grisold; C Weber; J Hainfellner; H Gisslinger; G Kasprian; E Auff; T Sycha; W Grisold

doi:10.1016/j.jns.2014.10.005

MRI negative meningeal myeloma with abducens nerve palsies responding to intrathecal chemotherapy

J Neurol Sci. 2014 Dec 15;347(1-2):359-60. doi: 10.1016/j.jns.2014.10.005. Epub 2014 Oct 29.

Authors

A Grisold¹, C Weber², J Hainfellner³, H Gisslinger⁴, G Kasprian⁵, E Auff², T Sycha², W Grisold⁶

Affiliations

¹ Department of Neurology, Medical University of Vienna, Austria. Electronic address: [email protected].
² Department of Neurology, Medical University of Vienna, Austria.
³ Institute of Neurology, Medical University of Vienna, Austria.
⁴ Department of Internal Medicine, Medical University of Vienna, Austria.
⁵ Department of Radiology, Medical University of Vienna, Austria.
⁶ Department of Neurology, Kaiser Franz Josef Hospital of Vienna, Austria.

PMID: 25456462
DOI: 10.1016/j.jns.2014.10.005

Abstract

Meningeal involvement of multiple myeloma is rare. A patient with multiple myeloma presented with bilateral abducens nerve palsies. In the MRI neither lytic skull lesions nor meningeal enhancement could be found. The diagnosis was based on CSF studies and cytology. A neurologic remission was achieved with intrathecal chemotherapy.

Keywords: Complete CNS remission; Intrathecal chemotherapy; Leptomeningeal involvement; Multiple myeloma; Negative MRI.

Publication types

Case Reports

MeSH terms

Abducens Nerve Diseases / drug therapy*
Abducens Nerve Diseases / etiology
Abducens Nerve Diseases / pathology*
Aged
Drug Therapy / methods*
Humans
Injections, Spinal / methods
Magnetic Resonance Imaging*
Male
Multiple Myeloma / complications*
Multiple Myeloma / pathology
Treatment Outcome