Diels-Alder adducts with PTP1B inhibition from Morus notabilis

Phytochemistry. 2015 Jan:109:140-6. doi: 10.1016/j.phytochem.2014.10.015. Epub 2014 Nov 7.

Abstract

Eight Diels-Alder adducts, morbilisins A-H (1-8), a known analogue, chalcomoracin (9), together with eleven known flavonoids and 2-arylbenzofurans, were isolated from the leaves of Morus notabilis. Their structures were elucidated by extensive spectroscopic analysis, including 1D, 2D NMR, MS, and ECD data. Compounds 1, 5, and 7-9 showed inhibition against PTP1B phosphatase activity in vitro.

Keywords: Diels–Alder adducts; Moraceae; Morbilisins A–H; Morus notabilis; Protein tyrosine phosphatase 1B.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzofurans / chemistry*
  • Benzofurans / isolation & purification
  • Flavonoids / chemistry
  • Molecular Structure
  • Morus / chemistry*
  • Plant Leaves / chemistry*
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1 / antagonists & inhibitors*

Substances

  • Benzofurans
  • Flavonoids
  • chalcomoracin
  • morbilisin
  • PTPN1 protein, human
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1