Dermal group 2 innate lymphoid cells in atopic dermatitis and allergy

Ben Roediger; Ryan Kyle; Graham Le Gros; Wolfgang Weninger

doi:10.1016/j.coi.2014.10.008

Dermal group 2 innate lymphoid cells in atopic dermatitis and allergy

Curr Opin Immunol. 2014 Dec:31:108-14. doi: 10.1016/j.coi.2014.10.008. Epub 2014 Oct 28.

Authors

Ben Roediger¹, Ryan Kyle², Graham Le Gros³, Wolfgang Weninger⁴

Affiliations

¹ The Centenary Institute, Newtown, NSW 2042, Australia; Discipline of Dermatology, Sydney Medical School, University of Sydney, NSW 2006, Australia. Electronic address: [email protected].
² Malaghan Institute of Medical Research, Wellington, New Zealand.
³ Malaghan Institute of Medical Research, Wellington, New Zealand; Victoria University of Wellington, Wellington, New Zealand.
⁴ The Centenary Institute, Newtown, NSW 2042, Australia; Discipline of Dermatology, Sydney Medical School, University of Sydney, NSW 2006, Australia; Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia. Electronic address: [email protected].

PMID: 25459002
DOI: 10.1016/j.coi.2014.10.008

Abstract

Type 2 immune responses in the skin cause a variety of pathologies, including urticaria and atopic dermatitis. Traditionally, CD4(+) helper T cells have been implicated in the pathogenesis of these conditions. However, recently a new player, the group 2 innate lymphoid (ILC2) cell, has emerged as an important contributor to skin allergies. In this review, we summarize our current knowledge of the role ILC2 cells play in the physiology and pathology of mouse and human skin.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Dermatitis, Atopic / immunology*
Dermatitis, Atopic / pathology
Humans
Immunity, Innate*
Lymphocytes / immunology*
Lymphocytes / pathology
Mice
Skin / immunology*
Skin / pathology
Urticaria / immunology*
Urticaria / pathology