E-cadherin, guardian of liver physiology

Ester Gonzalez-Sanchez; Javier Vaquero; Laura Fouassier; Nicolas Chignard

doi:10.1016/j.clinre.2014.09.008

E-cadherin, guardian of liver physiology

Clin Res Hepatol Gastroenterol. 2015 Feb;39(1):3-6. doi: 10.1016/j.clinre.2014.09.008. Epub 2014 Nov 12.

Authors

Ester Gonzalez-Sanchez¹, Javier Vaquero¹, Laura Fouassier¹, Nicolas Chignard²

Affiliations

¹ Inserm UMR_S 938, centre de recherche Saint-Antoine, 75012 Paris, France; Sorbonne universités, UPMC, université Paris 06, 75012 Paris, France.
² Inserm UMR_S 938, centre de recherche Saint-Antoine, 75012 Paris, France; Sorbonne universités, UPMC, université Paris 06, 75012 Paris, France. Electronic address: [email protected].

PMID: 25459993
DOI: 10.1016/j.clinre.2014.09.008

Abstract

E-cadherin is a cell-to-cell adhesion molecule involved in epithelial cell behavior, tissue formation and cancer suppression. In the liver, E-cadherin is expressed by hepatocytes and biliary epithelial cells. However, the exact role of E-cadherin in hepatic pathophysiology remains largely unknown. Recently, specific loss of E-cadherin in liver epithelial cells has been shown to favor periportal fibrosis, periportal inflammation and liver cancer progression, suggesting that E-cadherin is a central liver protector.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Cadherins / metabolism*
Carcinogenesis*
Cholangitis, Sclerosing / metabolism*
Gene Expression Regulation, Neoplastic*
Liver Neoplasms / metabolism*
Male

Substances

Cadherins