Effective treatment of d-penicillamine induced elastosis perforans serpiginosa with ALA-PDT

Photodiagnosis Photodyn Ther. 2015 Mar;12(1):140-2. doi: 10.1016/j.pdpdt.2014.11.001. Epub 2014 Nov 22.

Abstract

A case of D-penicillamine(DPA) induced elastosis perforans serpiginosa(EPS) in a 32-year-old Chinese man was reported. The presentation lasted two years and was refractory to traditional medical treatment. He was then commenced on 7.6% 5-aminolevulinic acid (ALA) induced photodynamic therapy(PDT) by a LED light of 633 nm at dose levels of 130J/ cm2 for each session with total 3 sessions at one week interval. The patient was tolerated and responded well to this new approach for DPA-induced EPS without any adverse events. The etiology, pathophysiology, natural history, and treatment options for DPA-induced EPS are reviewed, and the authors suggest this method of treatment to be effective and safe for patients of DPA-induced EPS refractory to conventional therapy.

Keywords: 5-Aminolevulinic acid; Elastosis perforans serpiginosa; Photodynamic therapy; d-Penicillamine.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aminolevulinic Acid / therapeutic use*
  • Chelating Agents / administration & dosage
  • Chelating Agents / adverse effects
  • Humans
  • Male
  • Penicillamine / adverse effects*
  • Penicillamine / therapeutic use
  • Photochemotherapy / methods*
  • Photosensitizing Agents / therapeutic use
  • Pruritus / complications
  • Pruritus / drug therapy
  • Skin Diseases / chemically induced*
  • Skin Diseases / drug therapy*
  • Skin Diseases / pathology
  • Treatment Outcome

Substances

  • Chelating Agents
  • Photosensitizing Agents
  • Aminolevulinic Acid
  • Penicillamine

Supplementary concepts

  • Elastosis perforans serpiginosa