KCa1.1 β4-subunits are not responsible for iberiotoxin-resistance in baroreceptor neurons in adult male rats

Wen-Xiao Xu; Tao Ban; Lu-Qi Wang; Miao Zhao; Lei Yin; Guo Li; Hanying Chen; John Schield; Guo-Fen Qiao; Jing-Long Yan; Bai-Yan Li

doi:10.1016/j.ijcard.2014.10.128

KCa1.1 β4-subunits are not responsible for iberiotoxin-resistance in baroreceptor neurons in adult male rats

Int J Cardiol. 2015 Jan 15:178:184-7. doi: 10.1016/j.ijcard.2014.10.128. Epub 2014 Oct 23.

Authors

Wen-Xiao Xu¹, Tao Ban², Lu-Qi Wang², Miao Zhao², Lei Yin², Guo Li², Hanying Chen³, John Schield⁴, Guo-Fen Qiao², Jing-Long Yan⁵, Bai-Yan Li⁶

Affiliations

¹ Department of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
² Department of Pharmacology and Key Laboratory of Cardiovascular Research of Ministry of Education, Harbin Medical University, Harbin, China.
³ Riley Heart Research Center, Division of Pediatric Cardiology, Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, USA.
⁴ Department of Biomedical Engineering, Indiana University-Purdue University Indianapolis, Indianapolis, USA.
⁵ Department of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address: [email protected].
⁶ Department of Pharmacology and Key Laboratory of Cardiovascular Research of Ministry of Education, Harbin Medical University, Harbin, China. Electronic address: [email protected].

PMID: 25464250
DOI: 10.1016/j.ijcard.2014.10.128

No abstract available

Keywords: Baroreceptor neurons; Large conductance of Ca(2+)-activated K(+) channel; Modulatory β4-subunit; Pore-forming α-subunit; Single-cell RT-PCR; Whole-cell patch technique.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Drug Resistance / drug effects
Drug Resistance / physiology
Large-Conductance Calcium-Activated Potassium Channel alpha Subunits / antagonists & inhibitors
Large-Conductance Calcium-Activated Potassium Channel alpha Subunits / physiology*
Male
Neurons / drug effects
Neurons / physiology*
Peptides / pharmacology*
Pressoreceptors / drug effects
Pressoreceptors / physiology*
Protein Subunits / antagonists & inhibitors
Protein Subunits / physiology*
Rats
Rats, Sprague-Dawley
Scorpion Venoms / pharmacology*

Substances

Kcnma1 protein, rat
Large-Conductance Calcium-Activated Potassium Channel alpha Subunits
Peptides
Protein Subunits
Scorpion Venoms
iberiotoxin