Catecholamine melanins. Structural changes induced by copper ions

Biochim Biophys Acta. 1989 Jul 27;997(1-2):49-54. doi: 10.1016/0167-4838(89)90134-9.

Abstract

Melanins synthesized from adrenaline and dopamine in the presence or absence of copper ions were characterized by pyrolysis-gas chromatography-mass spectrometry and by IR and ESR methods. It was shown that Cu2+ are able to induce changes in the melanin structure. Melanins obtained from adrenaline-Cu2+ and dopamine-Cu2+ complexes are composed mainly from monomeric units of the indole type. Melanins synthesized from these catecholamines without Cu2+ contain additionally large amounts of unindolized monomeric units. The structure differences in both types of melanins are reflected in their sorptive abilities and spectroscopic characteristics.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chloroquine / metabolism
  • Copper / physiology*
  • Dopamine / metabolism*
  • Electron Spin Resonance Spectroscopy
  • Epinephrine / metabolism*
  • Gas Chromatography-Mass Spectrometry
  • In Vitro Techniques
  • Melanins / analysis
  • Melanins / biosynthesis*
  • Molecular Structure
  • Spectrophotometry, Infrared

Substances

  • Melanins
  • Copper
  • Chloroquine
  • Dopamine
  • Epinephrine