Abstract
We have identified two related series of dibenzazepine and dibenzoxazepine sodium channel blockers, which showed good potency on Nav1.7 in FLIPR-based and electrophysiological functional assays.
MeSH terms
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Animals
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Dibenzazepines / chemistry*
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Dibenzazepines / pharmacology
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Dibenzoxazepines / chemistry*
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Dibenzoxazepines / pharmacology
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Humans
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Microsomes, Liver / drug effects
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Microsomes, Liver / physiology
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NAV1.7 Voltage-Gated Sodium Channel / physiology*
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Rats
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Sodium Channel Blockers / chemistry*
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Sodium Channel Blockers / pharmacology
Substances
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Dibenzazepines
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Dibenzoxazepines
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NAV1.7 Voltage-Gated Sodium Channel
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Sodium Channel Blockers
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dibenzazepine