In vitro sensitivity of human herpesvirus-6 to antiviral drugs

Res Virol. 1989 May-Jun;140(3):219-28. doi: 10.1016/s0923-2516(89)80099-8.

Abstract

We studied the sensitivity of human herpesvirus-6 (HHV-6) to 4 antiviral drugs known to be effective in the treatment of infections with other human herpesviruses and human immunodeficiency virus. HHV-6 was grown in peripheral blood lymphocytes, and virus multiplication was quantified by evaluation of the cytopathic effect by molecular hybridization and indirect immunofluorescence assay. The 50% and 90% inhibitory concentrations (IC50 and IC90) were determined for each drug. The results obtained by the 3 different quantification techniques were found to correlate, and enabled us to conclude that HHV-6 replication was readily inhibited by foscarnet or ganciclovir. In contrast, inhibition of HHV-6 replication was observed only at high concentrations of acyclovir, and was not detected at the tested concentrations of zidovudine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / pharmacology*
  • Cytomegalovirus / drug effects
  • Cytopathogenic Effect, Viral
  • Dose-Response Relationship, Drug
  • Fluorescent Antibody Technique
  • Herpesviridae / drug effects*
  • Humans
  • Microbial Sensitivity Tests

Substances

  • Antiviral Agents