Combination of two candidate subunit vaccine antigens elicits protective immunity to ricin and anthrax toxin in mice

Vaccine. 2015 Jan 9;33(3):417-21. doi: 10.1016/j.vaccine.2014.11.036. Epub 2014 Dec 2.

Abstract

In an effort to develop combination vaccines for biodefense, we evaluated a ricin subunit antigen, RiVax, given in conjunction with an anthrax protective antigen, DNI. The combination led to high endpoint titer antibody response, neutralizing antibodies, and protective immunity against ricin and anthrax lethal toxin. This is a natural combination vaccine, since both antigens are recombinant subunit proteins that would be given to the same target population.

Keywords: Antigen; Biodefense; Toxin; Vaccine.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Anthrax / prevention & control*
  • Anthrax Vaccines / administration & dosage
  • Anthrax Vaccines / immunology*
  • Antibodies, Neutralizing / blood
  • Antigens, Bacterial / immunology
  • Antitoxins / blood
  • Bacterial Toxins / antagonists & inhibitors*
  • Bacterial Toxins / immunology
  • Female
  • Mice, Inbred BALB C
  • Poisoning / prevention & control*
  • Ricin / antagonists & inhibitors*
  • Ricin / immunology
  • Survival Analysis
  • Vaccines / administration & dosage
  • Vaccines / immunology*
  • Vaccines, Combined / administration & dosage
  • Vaccines, Combined / immunology
  • Vaccines, Subunit / administration & dosage
  • Vaccines, Subunit / immunology

Substances

  • Anthrax Vaccines
  • Antibodies, Neutralizing
  • Antigens, Bacterial
  • Antitoxins
  • Bacterial Toxins
  • RiVax
  • Vaccines
  • Vaccines, Combined
  • Vaccines, Subunit
  • anthrax toxin
  • Ricin