Augmented TGFβ receptor signaling induces apoptosis of pancreatic carcinoma cells

Chenggang Li; Zhiming Zhao; Zhipeng Zhou; Rong Liu

doi:10.1007/s13277-014-2908-7

Augmented TGFβ receptor signaling induces apoptosis of pancreatic carcinoma cells

Tumour Biol. 2015 Apr;36(4):2815-9. doi: 10.1007/s13277-014-2908-7. Epub 2014 Dec 5.

Authors

Chenggang Li¹, Zhiming Zhao, Zhipeng Zhou, Rong Liu

Affiliation

¹ Department of Surgical Oncology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China, [email protected].

PMID: 25476855
DOI: 10.1007/s13277-014-2908-7

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is an extremely malignant tumor in humans. Thus, understanding the tumorigenesis of PDAC appears to help develop efficient therapy. Here, we show that activated TGFβ receptor signaling induces apoptosis of pancreatic carcinoma cells in vitro and in vivo, suggesting that activation of TGFβ receptor signaling may prevent development of PDAC.

Publication types

Retracted Publication

MeSH terms

Apoptosis / genetics
Carcinogenesis*
Carcinoma, Pancreatic Ductal / genetics*
Carcinoma, Pancreatic Ductal / pathology
Cell Line, Tumor
Cell Proliferation / genetics*
Gene Expression Regulation, Neoplastic
Humans
Receptors, Transforming Growth Factor beta / genetics*
Receptors, Transforming Growth Factor beta / metabolism
Signal Transduction / genetics
Transforming Growth Factor beta / genetics

Substances

Receptors, Transforming Growth Factor beta
Transforming Growth Factor beta