Dominance hierarchy arising from the evolution of a complex small RNA regulatory network

Science. 2014 Dec 5;346(6214):1200-5. doi: 10.1126/science.1259442.

Abstract

The prevention of fertilization through self-pollination (or pollination by a close relative) in the Brassicaceae plant family is determined by the genotype of the plant at the self-incompatibility locus (S locus). The many alleles at this locus exhibit a dominance hierarchy that determines which of the two allelic specificities of a heterozygous genotype is expressed at the phenotypic level. Here, we uncover the evolution of how at least 17 small RNA (sRNA)-producing loci and their multiple target sites collectively control the dominance hierarchy among alleles within the gene controlling the pollen S-locus phenotype in a self-incompatible Arabidopsis species. Selection has created a dynamic repertoire of sRNA-target interactions by jointly acting on sRNA genes and their target sites, which has resulted in a complex system of regulation among alleles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Arabidopsis / genetics*
  • Biological Evolution*
  • Gene Expression Regulation, Plant*
  • Gene Regulatory Networks*
  • Genes, Dominant*
  • Genes, Recessive*
  • Genetic Loci
  • Models, Molecular
  • Phylogeny
  • Pollination
  • RNA, Small Untranslated / classification
  • RNA, Small Untranslated / genetics*
  • Selection, Genetic

Substances

  • RNA, Small Untranslated