Pushing the limits: defeating leukemia stem cells by depleting telomerase

Ya-Huei Kuo; Ravi Bhatia

doi:10.1016/j.stem.2014.11.014

Pushing the limits: defeating leukemia stem cells by depleting telomerase

Cell Stem Cell. 2014 Dec 4;15(6):673-5. doi: 10.1016/j.stem.2014.11.014.

Authors

Ya-Huei Kuo¹, Ravi Bhatia²

Affiliations

¹ Division of Hematopoietic Stem Cell and Leukemia Research, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA. Electronic address: [email protected].
² Division of Hematopoietic Stem Cell and Leukemia Research, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA. Electronic address: [email protected].

Abstract

Leukemia stem cells (LSCs), featuring unlimited self-renewal capacity and chemoresistance, are critical cellular targets for new treatments to improve outcomes for acute myeloid leukemia (AML). In this issue of Cell Stem Cell, Bruedigam et al. (2014) demonstrate that inhibition of telomerase is damaging to LSCs and may represent a promising therapeutic approach in AML.

Publication types

Comment

MeSH terms

Animals
Humans
Indoles / administration & dosage*
Leukemia, Myeloid, Acute / drug therapy*
Neoplastic Stem Cells / drug effects*
Niacinamide / analogs & derivatives*
Telomerase / metabolism*
Tumor Suppressor Protein p53 / metabolism*

Substances

Indoles
Tumor Suppressor Protein p53
Niacinamide
Telomerase

Abstract

Publication types

MeSH terms

Substances

Grants and funding