The nucleolus gets the silent treatment

Cell Stem Cell. 2014 Dec 4;15(6):675-6. doi: 10.1016/j.stem.2014.11.017.

Abstract

In this issue of Cell Stem Cell, Savić et al. (2014) and Kim et al. (2014) provide insight into how global heterochromatin condensation and LIN28 sequestration in embryonic stem cells are independent mechanisms regulating pluripotency in the oft-overlooked nucleolus.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Nucleolus / metabolism*
  • Chromosomal Proteins, Non-Histone / metabolism*
  • Embryonic Stem Cells / physiology*
  • Genes, rRNA*
  • Humans
  • MicroRNAs / metabolism*
  • Neurons / physiology*
  • Pluripotent Stem Cells / physiology*
  • RNA, Long Noncoding / metabolism*
  • RNA-Binding Proteins / metabolism*

Substances

  • Chromosomal Proteins, Non-Histone
  • MicroRNAs
  • RNA, Long Noncoding
  • RNA-Binding Proteins