PcG methylation of the HIST1 cluster defines an epigenetic marker of acute myeloid leukemia

Leukemia. 2015 May;29(5):1202-6. doi: 10.1038/leu.2014.339. Epub 2014 Dec 8.

Authors

G Tiberi¹, A Pekowska², C Oudin¹, A Ivey³, A Autret¹, T Prebet¹, M Koubi¹, F Lembo¹, M-J Mozziconacci¹, G Bidaut¹, C Chabannon¹, D Grimwade⁴, N Vey¹, S Spicuglia², B Calmels¹, E Duprez¹

Affiliations

¹ CRCM (Epigenetic Factors in Normal and Malignant Hematopoiesis), Inserm, U1068; Institut Paoli-Calmettes; Aix-Marseille Université, UM105; CNRS, UMR7258, Marseille, France.
² CIML, CNRS UMR6102, INSERM U631, Aix-Marseille Université, Marseille, France.
³ 1] Department of Medical and Molecular Genetics, King's College London School of Medicine, London, UK [2] GSTS Pathology, Guy's Hospital, London, UK.
⁴ Department of Medical and Molecular Genetics, King's College London School of Medicine, London, UK.

PMID: 25482132
DOI: 10.1038/leu.2014.339

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Biomarkers / metabolism
Chromatin / metabolism
DNA Methylation*
Epigenesis, Genetic*
Female
Gene Expression Profiling
Gene Expression Regulation
Gene Expression Regulation, Leukemic
Histones / genetics*
Humans
Leukemia, Myeloid, Acute / genetics*
Male
Middle Aged
Multigene Family*
Mutation
Nuclear Proteins / genetics
Nucleophosmin

Substances

Biomarkers
Chromatin
Histones
Nuclear Proteins
Nucleophosmin

Grants and funding

RP-PG-0108-10093/DH_/Department of Health/United Kingdom