Bromodomain inhibition by JQ1 suppresses lipopolysaccharide-stimulated interleukin-6 secretion in multiple myeloma cells

Cytokine. 2015 Feb;71(2):415-7. doi: 10.1016/j.cyto.2014.11.013. Epub 2014 Dec 4.

Authors

Rohit R Ghurye¹, Helen J S Stewart¹, Timothy J Chevassut²

Affiliations

¹ Brighton and Sussex Medical School, Medical Research Building, University of Sussex, Falmer, Brighton BN1 9PS, UK.
² Brighton and Sussex Medical School, Medical Research Building, University of Sussex, Falmer, Brighton BN1 9PS, UK. Electronic address: [email protected].

PMID: 25482841
DOI: 10.1016/j.cyto.2014.11.013

No abstract available

Publication types

Letter

MeSH terms

Aged
Aged, 80 and over
Antibodies, Monoclonal / chemistry
Azepines / chemistry*
Cell Survival
Enzyme-Linked Immunosorbent Assay
Female
Gene Expression Regulation, Neoplastic*
Humans
Interleukin-6 / metabolism*
Lipopolysaccharides / chemistry*
Male
Multiple Myeloma / metabolism*
Protein Structure, Tertiary
Real-Time Polymerase Chain Reaction
Triazoles / chemistry*

Substances

(+)-JQ1 compound
Antibodies, Monoclonal
Azepines
IL6 protein, human
Interleukin-6
Lipopolysaccharides
Triazoles